作者
Saud Alarifi, Daoud Ali, Maqusood Ahamed, Maqsood A Siddiqui, Abdulaziz A Al-Khedhairy
发表日期
2013/1/8
期刊
International journal of nanomedicine
页码范围
189-199
出版商
Taylor & Francis
简介
Background
Cobalt oxide nanoparticles (Co3O4NPs) are increasingly recognized for their utility in biological applications, magnetic resonance imaging, and drug delivery. However, little is known about the toxicity of Co3O4NPs in human cells.
Methods
We investigated the possible mechanisms of genotoxicity induced byCo3O4NPs in human hepatocarcinoma (HepG2) cells. Cell viability,reactive oxygen species (ROS), glutathione, thiobarbituric acid reactive substance,apoptosis, and DNA damage were assessed in HepG2 cells afterCo3O4NPs and Co2+ exposure.
Results
Co3O4NPs elicited a significant (P < 0.01)reduction in glutathione with a concomitant increase in lipid hydroperoxide, ROSgeneration, superoxide dismutase, and catalase activity after 24- and 48-hour exposure.Co3O4NPs had a mild cytotoxic effect in HepG2 cells; however, itinduced ROS and oxidative stress, leading to DNA damage, a …
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S Alarifi, D Ali, M Ahamed, MA Siddiqui… - International journal of nanomedicine, 2013