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Understanding the toxic effects of nanoparticles on aquatic organism is the biggest obstacle to the safe development of nanotechnology. However, little is known about the toxic mechanisms of zinc oxide nanoparticles (ZnONPs) in freshwater snail Lymnaea luteola (L. luteola). This study was designed to investigate the possible mechanisms of genotoxicity induced by ZnONPs in freshwater snail L. luteola. ZnONPs (32μg/ml) elicited a significant (p<0.01) reduction in glutathione (42.10% and 61.40%), glutathione-S-transferase (25.60% and 40.24%) and glutathione peroxidase (21.73% and 39.13%) with a concomitant increase in malondialdehyde level (54.50% and 57.14%; p<0.01) and catalase (34.88% and 52.56%; p<0.01) in digestive gland of L. luteola after 24 and 96h exposure, respectively. However, a statistically significant (p<0.01) induction in DNA damage was observed by the comet assay in digestive …