作者
Ned H Latham, Joseph S Doyle, Anna Y Palmer, Joost W Vanhommerig, Paul Agius, Stelliana Goutzamanis, Zinia Li, Alisa Pedrana, Magnus Gottfredsson, Julie Bouscaillou, Niklas Luhmann, Alyona Mazhnaya, Frederick L Altice, Sahar Saeed, Marina Klein, Oluwaseun O Falade‐Nwulia, Esther Aspinall, Sharon Hutchinson, Margaret E Hellard, Rachel Sacks‐Davis
发表日期
2019/12
来源
Liver International
卷号
39
期号
12
页码范围
2244-2260
简介
Background and Aims
Direct‐acting antivirals (DAAs) are highly effective in treating hepatitis C. However, there is concern that cure rates may be lower, and reinfection rates higher, among people who inject drugs. We conducted a systematic review of treatment outcomes achieved with DAAs in people who inject drugs (PWID).
Methods
A search strategy was used to identify studies that reported sustained viral response (SVR), treatment discontinuation, adherence or reinfection in recent PWID and/or opioid substitution therapy (OST) recipients. Study quality was assessed using the Newcastle‐Ottawa Scale. Meta‐analysis of proportions was used to estimate pooled SVR and treatment discontinuation rates. The pooled relative risk of achieving SVR and pooled reinfection rate were calculated using generalized mixed effects linear models.
Results
The search identified 8075 references; 26 were eligible for …
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NH Latham, JS Doyle, AY Palmer, JW Vanhommerig… - Liver International, 2019