作者
Sihai Dave Zhao, Yi Li
发表日期
2012/2/1
期刊
Journal of multivariate analysis
卷号
105
期号
1
页码范围
397-411
出版商
Academic Press
简介
It is rather challenging for current variable selectors to handle situations where the number of covariates under consideration is ultra-high. Consider a motivating clinical trial of the drug bortezomib for the treatment of multiple myeloma, where overall survival and expression levels of 44760 probesets were measured for each of 80 patients with the goal of identifying genes that predict survival after treatment. This dataset defies analysis even with regularized regression. Some remedies have been proposed for the linear model and for generalized linear models, but there are few solutions in the survival setting and, to our knowledge, no theoretical support. Furthermore, existing strategies often involve tuning parameters that are difficult to interpret. In this paper, we propose and theoretically justify a principled method for reducing dimensionality in the analysis of censored data by selecting only the important covariates …
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