作者
Yuming Sun, Jian Kang, Chinmay Haridas, Nicholas Mayne, Alexandra Potter, Chi-Fu Yang, David C Christiani, Yi Li
发表日期
2024/3
期刊
Biometrics
卷号
80
期号
1
页码范围
ujad024
出版商
Oxford University Press
简介
Lung cancer is a leading cause of cancer mortality globally, highlighting the importance of understanding its mortality risks to design effective patient-centered therapies. The National Lung Screening Trial (NLST) employed computed tomography texture analysis, which provides objective measurements of texture patterns on CT scans, to quantify the mortality risks of lung cancer patients. Partially linear Cox models have gained popularity for survival analysis by dissecting the hazard function into parametric and nonparametric components, allowing for the effective incorporation of both well-established risk factors (such as age and clinical variables) and emerging risk factors (eg, image features) within a unified framework. However, when the dimension of parametric components exceeds the sample size, the task of model fitting becomes formidable, while nonparametric modeling grapples with the curse of …
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