作者
Ruth A Kleinerman, Chu-ling Yu, Mark P Little, Yi Li, David Abramson, Johanna Seddon, Margaret A Tucker
发表日期
2012/3/20
期刊
Journal of clinical oncology
卷号
30
期号
9
页码范围
950-957
出版商
American Society of Clinical Oncology
简介
Purpose
To evaluate the risk of second cancer (SC) in long-term survivors of retinoblastoma (Rb) according to classification of germline mutation, based on family history of Rb and laterality.
Patients and Methods
We assembled a cohort of 1,852 1-year survivors of Rb (bilateral, n = 1,036; unilateral, n = 816). SCs were ascertained by medical records and self-reports and confirmed by pathology reports. Classification of RB1 germline mutation, inherited or de novo, was inferred by laterality of Rb and positive family history of Rb. Standardized incidence ratios and cumulative incidence for all SCs combined and for soft tissue sarcomas, bone cancers, and melanoma were calculated. The influence of host- and therapy-related risk factors for SC was assessed by Poisson regression for bilateral survivors.
Results
We observed a relative risk (RR) of 1.37 (95% CI, 1.00 to 1.86) for SCs in bilateral survivors associated with …
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RA Kleinerman, C Yu, MP Little, Y Li, D Abramson… - Journal of clinical oncology, 2012