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Billions of people and many soils across the planet suffer from micronutrient (MN) deficiencies impairing human health. In general, fertilization of deficient soils, according to soil test, with MNs alone and in combination with nitrogen, phosphorous, and potassium (NPK) baseline treatment increases crop yield. The soil applied fertilizer-MN use efficiency (MUE) by crops is <5 % due to a lack of synchronization between the fertilizer-MN release and their crop demand during growth. Nanotechnology and biotechnology have the potential to play a prominent place in transforming agricultural systems and food production worldwide in the coming years. MNs added in microcapsules and nanocapsules, nanomaterials (NMs), and nanoparticles (NPs) are taken up and translocated within plants when grown to maturity, increasing crop yield and MN concentration in plants. Noteworthy, many of the effects of NPs and …