作者
Ann-Christina Brady, Mikaël M Martino, Eileen Pedraza, Steve Sukert, Antonello Pileggi, Camillo Ricordi, Jeffrey A Hubbell, Cherie L Stabler
发表日期
2013/12/1
期刊
Tissue Engineering Part A
卷号
19
期号
23-24
页码范围
2544-2552
出版商
Mary Ann Liebert, Inc.
简介
The transplantation of allogeneic islets in recent clinical trials has shown substantial promise as a therapy for type 1 diabetes; however, long-term insulin independence remains inadequate. This has been largely attributed to the current intravascular, hepatic transplant site, which exposes islets to mechanical and inflammatory stresses. A highly macroporous scaffold, housed within an alternative transplant site, can support an ideal environment for islet transplantation by providing three-dimensional distribution of islets, while permitting the infiltration of host vasculature. In the present study, we sought to evaluate the synergistic effect of a proangiogenic hydrogel loaded within the void space of a macroporous poly(dimethylsiloxane) (PDMS) scaffold on islet engraftment. The fibrin-based proangiogenic hydrogel tested presents platelet derived growth factor (PDGF-BB), via a fibronectin (FN) fragment containing growth …
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AC Brady, MM Martino, E Pedraza, S Sukert, A Pileggi… - Tissue Engineering Part A, 2013