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M ore than half a million people experience homelessness in the USA on a given night. This epidemic has triggered calls to bolster housing and social services for persons experiencing homelessness (PEH), with less attention to the complex medical needs of these patients. Yet poor health is both a cause of homelessness and an effect, and the healthcare system is poorly suited for PEH. Traditional medical office settings are often unwelcoming and difficult for PEH to navigate due to social, logistical, and health-related barriers. On the provider side, clinicians report that PEH are among the most challenging to care for given their interwoven health and social needs. Consequently, PEH commonly fail to receive basic primary healthcare services, leading to avoidable downstream emergency department (ED) and hospital utilization costing billions of dollars per year. 1 This article describes how “street medicine” can …