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—To develop valid and reliable instruments to assess the methodologic quality and clinical relevance of drug studies.

—We developed an instrument to assess the methodologic quality of articles reporting clinical research and an instrument to measure nonmethodologic measures of quality, such as clinical relevance, generalizability, and adherence to ethical standards. Each instrument was pretested by seven independent, masked reviewers and modified based on interrater agreement and content validity of individual items. We determined correlational validity of the final methodologic quality instrument by comparing quality scores assigned to 10 articles by means of our instrument and a previously published one.

—Clinical drug studies published in symposium proceedings and peer reviewed biomedical literature.

—Interrater reliability of overall quality scores …