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Results. There was high variability in the pain-time trend in response to continuous noxious electric stimulation with constant intensity between volunteers. During 10min of stimulation the decrease in pain was in the range of 20–100%. However, this response is highly reproducible within the same volunteer and could be used to characterize individual pain response.

Conclusion. A new experimental approach to characterize the human dynamical response to noxious stimuli has been proposed. The method is non-invasive and takes only 10 min. The tolerability and reproducibility profile supports the use of this new pain model for investigating pain mechanisms and the development of new pharmacological therapies. doi: 10.1016/j. ejpain. 2007.03. 470