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To the Editor: Coronavirus disease 2019 (COVID-19), an emerging disease of variable severity caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is primarily a respiratory illness, but manifestations vary widely, affecting multiple organ systems resulting in management dilemmas. 1 Many aspects of the disease are just being studied. We report a case of severe acute pancreatitis (AP) in association with hypertriglyceridemia and COVID-19 infection and discuss clinical implications. A 40-year-old obese (body mass index, 38.8 kg/m2) male patient with no known comorbidity was admitted to the hospital with a 2-day history of severe epigastric pain radiating to back. Oxygen saturation on admission was 96% on room air. Laboratory tests showed blood glucose of 288 mg/dL, elevated serum lipase of 1544 U/L (reference range, 1–82 U/L), serum bicarbonate of 21 mmol/L (reference range, 21 …