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The present study was designed to investigate the Antihyperlipidemic activity of alcoholic extract of Sphaeranthus indicus L. flower heads in atherogenic diet induced hyperlipidemia. Sphaeranthus indicus extract was administered in a dose of 500 mg/kg/day, po for eight days. Marked decrease in body weight, total cholesterol, triglyceride, and low-density lipoprotein and very low density lipoprotein whereas significant increases in the level of high-density lipoprotein were obtained after treatment with Sphaeranthus indicus extract. The present work indicates that, Sphaeranthus indicus extract in a dose of 500 mg/kg/day effectively suppressed the atherogenic diet induced hyperlipidemia in rats, suggesting the potential protective role in atherosclerosis.