作者
Aymeric Silvin, Nicolas Manel
发表日期
2015/2/1
来源
Current opinion in immunology
卷号
32
页码范围
54-60
出版商
Elsevier Current Trends
简介
Highlights
- Innate sensing of HIV-1 is at the interface of viral replication and immune responses.
- Innate immune sensing of HIV-1 may contribute to antiviral control or pathogenesis.
- Plasmacytoid dendritic cells produce interferon in response to HIV-1.
- HIV-1 avoids antiviral innate sensing by macrophages and dendritic cells.
- HIV-1 sensing in tonsilar CD4+ T cells induces inflammatory pyroptosis.
The ability to sense infections is primordial to preserve organisms. Immune cells express pathogen sensors that induct innate and adaptive immune responses. Understanding how HIV-1 infection defeats these responses in most individuals remains an outstanding challenge. Since HIV-1 targets immune cells, innate immune sensors are remarkably positioned at the nexus of viral replication and immunity. Here, we discuss recent studies that have revealed innate sensing mechanisms of HIV-1 infection in plasmacytoid dendritic …
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A Silvin, N Manel - Current opinion in immunology, 2015