作者
Laura J Bierut, Arpana Agrawal, Kathleen K Bucholz, Kimberly F Doheny, Cathy Laurie, Elizabeth Pugh, Sherri Fisher, Louis Fox, William Howells, Sarah Bertelsen, Anthony L Hinrichs, Laura Almasy, Naomi Breslau, Robert C Culverhouse, Danielle M Dick, Howard J Edenberg, Tatiana Foroud, Richard A Grucza, Dorothy Hatsukami, Victor Hesselbrock, Eric O Johnson, John Kramer, Robert F Krueger, Samuel Kuperman, Michael Lynskey, Karl Mann, Rosalind J Neuman, Markus M Nöthen, John I Nurnberger Jr, Bernice Porjesz, Monika Ridinger, Nancy L Saccone, Scott F Saccone, Marc A Schuckit, Jay A Tischfield, Jen C Wang, Marcella Rietschel, Alison M Goate, John P Rice, as part of the Gene, Environment Association Studies (GENEVA) Consortium
发表日期
2010/3/16
期刊
Proceedings of the National Academy of Sciences
卷号
107
期号
11
页码范围
5082-5087
出版商
National Academy of Sciences
简介
Excessive alcohol consumption is one of the leading causes of preventable death in the United States. Approximately 14% of those who use alcohol meet criteria during their lifetime for alcohol dependence, which is characterized by tolerance, withdrawal, inability to stop drinking, and continued drinking despite serious psychological or physiological problems. We explored genetic influences on alcohol dependence among 1,897 European-American and African-American subjects with alcohol dependence compared with 1,932 unrelated, alcohol-exposed, nondependent controls. Constitutional DNA of each subject was genotyped using the Illumina 1M beadchip. Fifteen SNPs yielded P < 10−5, but in two independent replication series, no SNP passed a replication threshold of P < 0.05. Candidate gene GABRA2, which encodes the GABA receptor α2 subunit, was evaluated independently. Five SNPs at GABRA2 …
引用总数
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