作者
Scott F Saccone, Anthony L Hinrichs, Nancy L Saccone, Gary A Chase, Karel Konvicka, Pamela AF Madden, Naomi Breslau, Eric O Johnson, Dorothy Hatsukami, Ovide Pomerleau, Gary E Swan, Alison M Goate, Joni Rutter, Sarah Bertelsen, Louis Fox, Douglas Fugman, Nicholas G Martin, Grant W Montgomery, Jen C Wang, Dennis G Ballinger, John P Rice, Laura Jean Bierut
发表日期
2007/1/1
期刊
Human molecular genetics
卷号
16
期号
1
页码范围
36-49
出版商
Oxford University Press
简介
Nicotine dependence is one of the world's leading causes of preventable death. To discover genetic variants that influence risk for nicotine dependence, we targeted over 300 candidate genes and analyzed 3713 single nucleotide polymorphisms (SNPs) in 1050 cases and 879 controls. The Fagerström test for nicotine dependence (FTND) was used to assess dependence, in which cases were required to have an FTND of 4 or more. The control criterion was strict: control subjects must have smoked at least 100 cigarettes in their lifetimes and had an FTND of 0 during the heaviest period of smoking. After correcting for multiple testing by controlling the false discovery rate, several cholinergic nicotinic receptor genes dominated the top signals. The strongest association was from an SNP representing CHRNB3 , the β3 nicotinic receptor subunit gene ( P = 9.4 × 10 −5 …
引用总数
学术搜索中的文章
SF Saccone, AL Hinrichs, NL Saccone, GA Chase… - Human molecular genetics, 2007