作者
Arpana Agrawal, Anthony L Hinrichs, Gerald Dunn, Sarah Bertelsen, Danielle M Dick, Scott F Saccone, Nancy L Saccone, Richard A Grucza, Jen C Wang, C Robert Cloninger, Howard J Edenberg, Tatiana Foroud, Victor Hesselbrock, John Kramer, Kathleen K Bucholz, Samuel Kuperman, John I Nurnberger Jr, Bernice Porjesz, Marc A Schuckit, Alison M Goate, Laura J Bierut
发表日期
2008/1/11
期刊
Drug and alcohol dependence
卷号
93
期号
1-2
页码范围
12-20
出版商
Elsevier
简介
Dependence on alcohol and illicit drugs frequently co-occur. Results from a number of twin studies suggest that heritable influences on alcohol dependence and drug dependence may substantially overlap. Using large, genetically informative pedigrees from the Collaborative Study on the Genetics of Alcoholism (COGA), we performed quantitative linkage analyses using a panel of 1717 SNPs. Genome-wide linkage analyses were conducted for quantitative measures of DSM-IV alcohol dependence criteria, cannabis dependence criteria and dependence criteria across any illicit drug (including cannabis) individually and in combination as an average score across alcohol and illicit drug dependence criteria. For alcohol dependence, LOD scores exceeding 2.0 were noted on chromosome 1 (2.0 at 213cM), 2 (3.4 at 234cM) and 10 (3.7 at 60cM). For cannabis dependence, a maximum LOD of 1.9 was noted at 95cM …
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A Agrawal, AL Hinrichs, G Dunn, S Bertelsen, DM Dick… - Drug and alcohol dependence, 2008