作者
Arpana Agrawal, Michele L Pergadia, Scott F Saccone, Anthony L Hinrichs, Christina N Lessov‐Schlaggar, Nancy L Saccone, Rosalind J Neuman, Naomi Breslau, Eric Johnson, Dorothy Hatsukami, Grant W Montgomery, Andrew C Heath, Nicholas G Martin, Alison M Goate, John P Rice, Laura J Bierut, Pamela AF Madden
发表日期
2008/6
期刊
Addiction
卷号
103
期号
6
页码范围
1027-1038
出版商
Blackwell Publishing Ltd
简介
Aims The gamma‐aminobutyric acid receptor A (GABRA) gene clusters on chromosomes 4 and 5 have been examined previously for their association with alcohol and drug dependence phenotypes. Compelling evidence suggests that GABRA2 is associated with alcohol and drug dependence. However, no study has investigated whether genes in the GABAA gene clusters are associated with nicotine dependence, an important phenotype with a high correlation to persistent smoking, the single most preventable cause of mortality world‐wide.
Design Using data on 1050 nicotine‐dependent cases and 879 non‐dependent smoking controls, we used logistic regression to examine the association between single nucleotide polymorphisms (SNPs) in 13 genes in the GABAA receptor system as well as GABBR2 (a GABAB gene).
Findings We found evidence for association between four SNPs in GABRA4, two …
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A Agrawal, ML Pergadia, SF Saccone, AL Hinrichs… - Addiction, 2008