作者
Marcus J Claesson, Ian B Jeffery, Susana Conde, Susan E Power, Eibhlís M O’connor, Siobhán Cusack, Hugh Harris, Mairead Coakley, Bhuvaneswari Lakshminarayanan, Orla O’sullivan, Gerald F Fitzgerald, Jennifer Deane, Michael O’connor, Norma Harnedy, Kieran O’connor, Denis O’mahony, Douwe Van Sinderen, Martina Wallace, Lorraine Brennan, Catherine Stanton, Julian R Marchesi, Anthony P Fitzgerald, Fergus Shanahan, Colin Hill, R Paul Ross, Paul W O’toole
发表日期
2012/8
期刊
Nature
卷号
488
期号
7410
页码范围
178-184
出版商
Nature Publishing Group
简介
Alterations in intestinal microbiota composition are associated with several chronic conditions, including obesity and inflammatory diseases. The microbiota of older people displays greater inter-individual variation than that of younger adults. Here we show that the faecal microbiota composition from 178 elderly subjects formed groups, correlating with residence location in the community, day-hospital, rehabilitation or in long-term residential care. However, clustering of subjects by diet separated them by the same residence location and microbiota groupings. The separation of microbiota composition significantly correlated with measures of frailty, co-morbidity, nutritional status, markers of inflammation and with metabolites in faecal water. The individual microbiota of people in long-stay care was significantly less diverse than that of community dwellers. Loss of community-associated microbiota correlated with …
引用总数
学术搜索中的文章
MJ Claesson, IB Jeffery, S Conde, SE Power… - Nature, 2012