作者
Victor M Corman, Ali M Albarrak, Ali Senosi Omrani, Mohammed M Albarrak, Mohamed Elamin Farah, Malak Almasri, Doreen Muth, Andrea Sieberg, Benjamin Meyer, Abdullah M Assiri, Tabea Binger, Katja Steinhagen, Erik Lattwein, Jaffar Al-Tawfiq, Marcel A Müller, Christian Drosten, Ziad A Memish
发表日期
2016/2/15
期刊
Clinical Infectious Diseases
卷号
62
期号
4
页码范围
477-483
出版商
Oxford University Press
简介
Background. The Middle East respiratory syndrome (MERS) coronavirus causes isolated cases and outbreaks of severe respiratory disease. Essential features of the natural history of disease are poorly understood.
Methods. We studied 37 adult patients infected with MERS coronavirus for viral load in the lower and upper respiratory tracts (LRT and URT, respectively), blood, stool, and urine. Antibodies and serum neutralizing activities were determined over the course of disease.
Results. One hundred ninety-nine LRT samples collected during the 3 weeks following diagnosis yielded virus RNA in 93% of tests. Average (maximum) viral loads were 5 × 106 (6 × 1010) copies/mL. Viral loads (positive detection frequencies) in 84 URT samples were 1.9 × 104 copies/mL (47.6%). Thirty-three percent of all 108 serum samples tested yielded viral …
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VM Corman, AM Albarrak, AS Omrani, MM Albarrak… - Clinical Infectious Diseases, 2016