作者
Anjali G Hinch, Arti Tandon, Nick Patterson, Yunli Song, Nadin Rohland, Cameron D Palmer, Gary K Chen, Kai Wang, Sarah G Buxbaum, Ermeg L Akylbekova, Melinda C Aldrich, Christine B Ambrosone, Christopher Amos, Elisa V Bandera, Sonja I Berndt, Leslie Bernstein, William J Blot, Cathryn H Bock, Eric Boerwinkle, Qiuyin Cai, Neil Caporaso, Graham Casey, L Adrienne Cupples, Sandra L Deming, W Ryan Diver, Jasmin Divers, Myriam Fornage, Elizabeth M Gillanders, Joseph Glessner, Curtis C Harris, Jennifer J Hu, Sue A Ingles, William Isaacs, Esther M John, WH Linda Kao, Brendan Keating, Rick A Kittles, Laurence N Kolonel, Emma Larkin, Loic Le Marchand, Lorna H McNeill, Robert C Millikan, Solomon Musani, Christine Neslund-Dudas, Sarah Nyante, George J Papanicolaou, Michael F Press, Bruce M Psaty, Alex P Reiner, Stephen S Rich, Jorge L Rodriguez-Gil, Jerome I Rotter, Benjamin A Rybicki, Ann G Schwartz, Lisa B Signorello, Margaret Spitz, Sara S Strom, Michael J Thun, Margaret A Tucker, Zhaoming Wang, John K Wiencke, John S Witte, Margaret Wrensch, Xifeng Wu, Yuko Yamamura, Krista A Zanetti, Wei Zheng, Regina G Ziegler, Xiaofeng Zhu, Susan Redline, Joel N Hirschhorn, Brian E Henderson, Herman A Taylor Jr, Alkes L Price, Hakon Hakonarson, Stephen J Chanock, Christopher A Haiman, James G Wilson, David Reich, Simon R Myers
发表日期
2011/8/11
期刊
Nature
卷号
476
期号
7359
页码范围
170-175
出版商
Nature Publishing Group UK
简介
Recombination, together with mutation, gives rise to genetic variation in populations. Here we leverage the recent mixture of people of African and European ancestry in the Americas to build a genetic map measuring the probability of crossing over at each position in the genome, based on about 2.1 million crossovers in 30,000 unrelated African Americans. At intervals of more than three megabases it is nearly identical to a map built in Europeans. At finer scales it differs significantly, and we identify about 2,500 recombination hotspots that are active in people of West African ancestry but nearly inactive in Europeans. The probability of a crossover at these hotspots is almost fully controlled by the alleles an individual carries at PRDM9 (P value < 10−245). We identify a 17-base-pair DNA sequence motif that is enriched in these hotspots, and is an excellent match to the predicted binding target of PRDM9 alleles …
学术搜索中的文章
AG Hinch, A Tandon, N Patterson, Y Song, N Rohland… - Nature, 2011