作者
Sami Alkayyali
发表日期
2015
来源
Lund University Faculty of Medicine Doctoral Dissertation Series
卷号
2015
期号
26
机构
Lund University
简介
Popular Abstract in English
Type 2 diabetes (T2D) is a polygenic disorder characterized by impaired insulin secretion or insulin action in which genes interact with the environment to cause the disease. T2D represent 90% of all patients with diabetes. The disease is increasing globally, with an estimated prevalence of 592 million affected by 2035. According to World Health Organization records, approximately 80% of diabetes-related mortality occurs in low- and middle-income countries.
The disease is associated with devastating complications such as chronic microvascular (nephropathy, retinopathy, and neuropathy) and macrovascular (coronary heart disease and stroke) consequences.
Hyperglycaemia and duration of disease were considered the strongest risk factors for development of diabetic complications. Prospective studies have demonstrated that some patients with T2D experience complications despite well-controlled blood glucose levels, whereas some patients with uncontrolled blood glucose levels with long disease duration do not experience any complications. These observations suggest that genetic factors might be operative in the predisposition to diabetic complications. Also, family studies have reported 50% heritability for ischemic heart disease, 36% to 75% for diabetes nephropathy, and 52% for diabetes retinopathy.
Our study aimed to (1) identify genetic markers associated with diabetic complications among patients with T2D, and (2) examine exposure of famine as a risk factor for progression to diabetes complications using susceptibility loci for cardiometabolic traits in T2D patients from Ukraine (a population with a high …
Type 2 diabetes (T2D) is a polygenic disorder characterized by impaired insulin secretion or insulin action in which genes interact with the environment to cause the disease. T2D represent 90% of all patients with diabetes. The disease is increasing globally, with an estimated prevalence of 592 million affected by 2035. According to World Health Organization records, approximately 80% of diabetes-related mortality occurs in low- and middle-income countries.
The disease is associated with devastating complications such as chronic microvascular (nephropathy, retinopathy, and neuropathy) and macrovascular (coronary heart disease and stroke) consequences.
Hyperglycaemia and duration of disease were considered the strongest risk factors for development of diabetic complications. Prospective studies have demonstrated that some patients with T2D experience complications despite well-controlled blood glucose levels, whereas some patients with uncontrolled blood glucose levels with long disease duration do not experience any complications. These observations suggest that genetic factors might be operative in the predisposition to diabetic complications. Also, family studies have reported 50% heritability for ischemic heart disease, 36% to 75% for diabetes nephropathy, and 52% for diabetes retinopathy.
Our study aimed to (1) identify genetic markers associated with diabetic complications among patients with T2D, and (2) examine exposure of famine as a risk factor for progression to diabetes complications using susceptibility loci for cardiometabolic traits in T2D patients from Ukraine (a population with a high …
学术搜索中的文章