作者
Elior Rahmani, Noah Zaitlen, Yael Baran, Celeste Eng, Donglei Hu, Joshua Galanter, Sam Oh, Esteban G Burchard, Eleazar Eskin, James Zou, Eran Halperin
发表日期
2016/5
期刊
Nature methods
卷号
13
期号
5
页码范围
443-445
出版商
Nature Publishing Group US
简介
In epigenome-wide association studies (EWAS), different methylation profiles of distinct cell types may lead to false discoveries. We introduce ReFACTor, a method based on principal component analysis (PCA) and designed for the correction of cell type heterogeneity in EWAS. ReFACTor does not require knowledge of cell counts, and it provides improved estimates of cell type composition, resulting in improved power and control for false positives in EWAS. Corresponding software is available at http://www.cs.tau.ac.il/~heran/cozygene/software/refactor.html.
学术搜索中的文章
E Rahmani, N Zaitlen, Y Baran, C Eng, D Hu… - Nature methods, 2016