作者
Bonnie R Joubert, Janine F Felix, Paul Yousefi, Kelly M Bakulski, Allan C Just, Carrie Breton, Sarah E Reese, Christina A Markunas, Rebecca C Richmond, Cheng-Jian Xu, Leanne K Küpers, Sam S Oh, Cathrine Hoyo, Olena Gruzieva, Cilla Söderhäll, Lucas A Salas, Nour Baïz, Hongmei Zhang, Johanna Lepeule, Carlos Ruiz, Symen Ligthart, Tianyuan Wang, Jack A Taylor, Liesbeth Duijts, Gemma C Sharp, Soesma A Jankipersadsing, Roy M Nilsen, Ahmad Vaez, M Daniele Fallin, Donglei Hu, Augusto A Litonjua, Bernard F Fuemmeler, Karen Huen, Juha Kere, Inger Kull, Monica Cheng Munthe-Kaas, Ulrike Gehring, Mariona Bustamante, Marie José Saurel-Coubizolles, Bilal M Quraishi, Jie Ren, Jörg Tost, Juan R Gonzalez, Marjolein J Peters, Siri E Håberg, Zongli Xu, Joyce B Van Meurs, Tom R Gaunt, Marjan Kerkhof, Eva Corpeleijn, Andrew P Feinberg, Celeste Eng, Andrea A Baccarelli, Sara E Benjamin Neelon, Asa Bradman, Simon Kebede Merid, Anna Bergström, Zdenko Herceg, Hector Hernandez-Vargas, Bert Brunekreef, Mariona Pinart, Barbara Heude, Susan Ewart, Jin Yao, Nathanaël Lemonnier, Oscar H Franco, Michael C Wu, Albert Hofman, Wendy McArdle, Pieter Van der Vlies, Fahimeh Falahi, Matthew W Gillman, Lisa F Barcellos, Ashish Kumar, Magnus Wickman, Stefano Guerra, Marie-Aline Charles, John Holloway, Charles Auffray, Henning W Tiemeier, George Davey Smith, Dirkje Postma, Marie-France Hivert, Brenda Eskenazi, Martine Vrijheid, Hasan Arshad, Josep M Antó, Abbas Dehghan, Wilfried Karmaus, Isabella Annesi-Maesano, Jordi Sunyer, Akram Ghantous, Göran Pershagen, Nina Holland, Susan K Murphy, Dawn L DeMeo, Esteban G Burchard, Christine Ladd-Acosta, Harold Snieder, Wenche Nystad, Gerard H Koppelman, Caroline L Relton, Vincent WV Jaddoe, Allen Wilcox, Erik Melén, Stephanie J London
发表日期
2016/4/7
期刊
The American Journal of Human Genetics
卷号
98
期号
4
页码范围
680-696
出版商
Elsevier
简介
Epigenetic modifications, including DNA methylation, represent a potential mechanism for environmental impacts on human disease. Maternal smoking in pregnancy remains an important public health problem that impacts child health in a myriad of ways and has potential lifelong consequences. The mechanisms are largely unknown, but epigenetics most likely plays a role. We formed the Pregnancy And Childhood Epigenetics (PACE) consortium and meta-analyzed, across 13 cohorts (n = 6,685), the association between maternal smoking in pregnancy and newborn blood DNA methylation at over 450,000 CpG sites (CpGs) by using the Illumina 450K BeadChip. Over 6,000 CpGs were differentially methylated in relation to maternal smoking at genome-wide statistical significance (false discovery rate, 5%), including 2,965 CpGs corresponding to 2,017 genes not previously related to smoking and methylation in …
学术搜索中的文章
BR Joubert, JF Felix, P Yousefi, KM Bakulski, AC Just… - The American Journal of Human Genetics, 2016