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This paper proposes a deep neural network (DNN) model using the reduced input feature space of Parkinson’s telemonitoring dataset to predict Parkinson’s disease (PD) progression. PD is a chronic and progressive nervous system disorder that affects body movement. PD is assessed by using the unified Parkinson’s disease rating scale (UPDRS). In this paper, firstly, principal component analysis (PCA) is employed to the featured dataset to address the multicollinearity problems in the dataset and to reduce the dimension of input feature space. Then, the reduced input feature space is fed into the proposed DNN model with a tuned parameter norm penalty (L2) and analyses the prediction performance of it in PD progression by predicting Motor and Total-UPDRS score. The model’s performance is evaluated by conducting several experiments and the result is compared with the result of previously …