作者
Ning Dong, Yu Zeng, Yao Wang, Congcong Liu, Jiayue Lu, Chang Cai, Xue Liu, Yongkui Chen, Yuchen Wu, Yinfei Fang, Yulin Fu, Yanyan Hu, Hongwei Zhou, Jiachang Cai, Fupin Hu, Shaolin Wang, Yang Wang, Yongning Wu, Gongxiang Chen, Zhangqi Shen, Sheng Chen, Rong Zhang
发表日期
2022/11/1
期刊
The Lancet Microbe
卷号
3
期号
11
页码范围
e846-e856
出版商
Elsevier
简介
Background
TMexCD1-TOprJ1, which is associated with phenotypic resistance to multiple classes of antibiotics, is a transmissible resistance-nodulation-division (RND) family efflux pump. However, the prevalence and genomic and phenotypic characteristics of clinical isolates with this important resistance determinant are poorly understood. In this study, we aimed to survey tmexCD-toprJ among clinical Gram-negative isolates collected from hospitals in China between 1991 and 2020 and characterise tmexCD-toprJ-positive clinical isolates.
Methods
We conducted online data retrieval and active nationwide surveillance in China to screen tmexCD-toprJ-positive strains. We characterised tmexCD-toprJ-positive clinical strains for their antimicrobial susceptibility, genetic and functional characteristics, and the potential inter-species transmission route of tmexCD-toprJ with whole genome sequencing and bioinformatics …
学术搜索中的文章
N Dong, Y Zeng, Y Wang, C Liu, J Lu, C Cai, X Liu… - The Lancet Microbe, 2022