作者
Atherton PJ. Brook MS, Wilkinson DJ, Mitchell WK, Lund JN, Phillips BE, Szewczyk NJ, Greenhaff PL, Smith K
发表日期
2016/12/15
期刊
J Physiol
卷号
594
期号
24
页码范围
7399-7417
简介
Key points
- Resistance exercise training (RET) is one of the most effective strategies for preventing declines in skeletal muscle mass and strength with age.
- Hypertrophic responses to RET with age are diminished compared to younger individuals.
- In response to 6 weeks RET, we found blunted hypertrophic responses with age are underpinned by chronic deficits in long‐term muscle protein synthesis.
- We show this is likely to be the result of multifactorial deficits in anabolic hormones and blunted translational efficiency and capacity.
- These results provide great insight into age‐related exercise adaptations and provide a platform on which to devise appropriate nutritional and exercise interventions on a longer term basis.
Abstract
Ageing is associated with impaired hypertrophic responses to resistance exercise training (RET). Here we investigated the aetiology of ‘anabolic resistance’ in older humans. Twenty healthy …
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MS Brook, DJ Wilkinson, WK Mitchell, JN Lund… - The Journal of physiology, 2016