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Probiotic bacteria exhibit a variety of properties, which are unique to a particular strain. Lactobacillus acidophilus-SDC 2012, 2013 are new strains isolated from Korean infants’ feces. The potential utility of Lactobacillus acidophilus-SDC 2012, 2013 in irritable bowel syndrome (IBS) was studied. Forty IBS patients were randomized into a placebo (n= 20) and probiotics group (n= 20). Four weeks of treatment with L. acidophilus-SDC 2012, 2013 was associated with a reduced score for abdominal pain or discomfort compared to the baseline (P= 0.011). The percent reduction in abdominal pain or discomfort exceeded the placebo scores by more than 20%(23.8 and 0.2% for probiotics and placebo, respectively, P= 0.003). There was a significant difference in the proportion of responders between the probiotics and placebo groups (P= 0.011). There was no drop out or adverse events for either group during the study …