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Purpose: In vivo measurement of thickness in individual retinal layers provides important information on the relationship between refractive development, eye growth and retinal morphology. In our lab, we previously studied how the overall retinal thickness (RT) changes with age in marmoset eyes. The purpose of this study was to evaluate the change in thickness in individual retinal layers in relation to the change in refractive error (Rx) and vitreous chamber depth (VCD) in marmoset eyes.

Methods: Twenty-two eyes of 14 marmosets were treated for 10 weeks with negative (-5/-10D) and positive (+ 5D) soft contact lenses to induce myopia and hyperopia respectively. VCD, cycloplegic Rx and RT were measured using a high frequency A-scan ultrasound, Nidek autorefractor and Bioptigen SD-OCT (12x12mm 2, 100B-scans, 1000A-scans/B-scan) respectively at baseline (≈ 70 days) and end of treatment (≈ 150 days …