作者
Steven P Rowe, Katarzyna J Macura, Esther Mena, Amanda L Blackford, Rosa Nadal, Emmanuel S Antonarakis, Mario Eisenberger, Michael Carducci, Hong Fan, Robert F Dannals, Ying Chen, Ronnie C Mease, Zsolt Szabo, Martin G Pomper, Steve Y Cho
发表日期
2016/6
期刊
Molecular imaging and biology
卷号
18
页码范围
411-419
出版商
Springer US
简介
Purpose
Current standard of care conventional imaging modalities (CIM) such as X-ray computed tomography (CT) and bone scan can be limited for detection of metastatic prostate cancer and therefore improved imaging methods are an unmet clinical need. We evaluated the utility of a novel second-generation low molecular weight radiofluorinated prostate-specific membrane antigen (PSMA)-targeted positron emission tomography (PET) radiotracer, [18F]DCFPyL, in patients with metastatic prostate cancer.
Procedures
Nine patients with suspected prostate cancer recurrence, eight with CIM evidence of metastatic prostate cancer and one with biochemical recurrence, were imaged with [18F]DCFPyL PET/CT. Eight of the patients had contemporaneous CIM for comparison. A lesion-by-lesion comparison of the detection of suspected sites of metastatic …
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SP Rowe, KJ Macura, E Mena, AL Blackford, R Nadal… - Molecular imaging and biology, 2016