作者
Kristin Köhler-Forsberg, Vibeke H Dam, Brice Ozenne, Anjali Sankar, Vincent Beliveau, Elizabeth B Landman, Søren V Larsen, Asbjørn S Poulsen, Cheng-Teng Ip, Anders Jørgensen, Michal Meyer, Dea S Stenbæk, Hans RL Eiberg, Jacob Madsen, Claus Svarer, Martin B Jørgensen, Vibe G Frokjaer, Gitte M Knudsen
发表日期
2023/4/1
期刊
JAMA psychiatry
卷号
80
期号
4
页码范围
296-304
出版商
American Medical Association
简介
Importance
The cerebral serotonin 4 (5-HT4) receptor is a promising novel target for treatment of major depressive disorder (MDD), and pharmacological stimulation of the 5-HT4receptor has been associated with improved learning and memory in healthy individuals.
Objective
To map the neurobiological signatures of patients with untreated MDD compared with healthy controls and to examine the association between cerebral 5-HT4receptor binding and cognitive functions in the depressed state.
Design, Setting, and Participants
This case-control study used baseline data from the NeuroPharm clinical depression trial in Denmark. Adult participants included antidepressant-free outpatients with a current moderate to severe depressive episode and healthy controls. All participants completed positron emission tomography (PET) scanning with [11C]SB207145 for quantification of brain 5-HT4receptor binding, but only the …
学术搜索中的文章
K Köhler-Forsberg, VH Dam, B Ozenne, A Sankar… - JAMA psychiatry, 2023