作者
Olga Marshall, Hanzhang Lu, Jean-Christophe Brisset, Feng Xu, Peiying Liu, Joseph Herbert, Robert I Grossman, Yulin Ge
发表日期
2014/10/1
期刊
JAMA neurology
卷号
71
期号
10
页码范围
1275-1281
出版商
American Medical Association
简介
Importance
Cerebrovascular reactivity (CVR) is an inherent indicator of the dilatory capacity of cerebral arterioles for a vasomotor stimulus for maintaining a spontaneous and instant increase of cerebral blood flow (CBF) in response to neural activation. The integrity of this mechanism is essential to preserving healthy neurovascular coupling; however, to our knowledge, no studies have investigated whether there are CVR abnormalities in multiple sclerosis (MS).
Objective
To use hypercapnic perfusion magnetic resonance imaging to assess CVR impairment in patients with MS.
Design, Setting, and Participants
A total of 19 healthy volunteers and 19 patients with MS underwent perfusion magnetic resonance imaging based on pseudocontinuous arterial spin labeling to measure CBF at normocapnia (ie, breathing room air) and hypercapnia. The hypercapnia condition is achieved by breathing 5% carbon dioxide gas …
学术搜索中的文章
O Marshall, H Lu, JC Brisset, F Xu, P Liu, J Herbert… - JAMA neurology, 2014