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Cerebral metabolic rate of oxygen (CMRO₂) is an important index of tissue viability and brain function, but this parameter cannot yet be measured routinely on clinical scanners. Recently, a noninvasive technique was proposed which estimates global CMRO₂ by concomitantly measuring oxygen‐extraction‐fraction using T₂‐relaxation‐under‐spin‐tagging MRI and pulse oximetry, and cerebral‐blood‐flow using phase‐contrast MRI. This study sought to establish a standard acquisition procedure for this technique and to evaluate its test–retest reproducibility in healthy subjects. Each subject was examined in five sessions and each session included two measurements. Intrasession, intersession, and intersubject coefficients of variation for CMRO₂ were found to be 3.84 ± 1.44% (N = 7, mean ± standard deviation), 6.59 ± 1.56%, and 8.80% respectively. These reproducibility values were comparable or slightly …