作者
Peiying Liu, Hao Huang, Nancy Rollins, Lina F Chalak, Tina Jeon, Cathy Halovanic, Hanzhang Lu
发表日期
2014/3
期刊
NMR in Biomedicine
卷号
27
期号
3
页码范围
332-340
出版商
John Wiley & Sons, Ltd.
简介
The cerebral metabolic rate of oxygen (CMRO2) is the rate of oxygen consumption by the brain, and is thought to be a direct index of energy homeostasis and brain health. However, in vivo measurement of CMRO2 is challenging, in particular for the neonatal population, in whom conventional radiotracer methods are not applicable because of safety concerns. In this study, we propose a method to quantify global CMRO2 in neonates based on arteriovenous differences in oxygen content, and employ separate measurements of oxygenation and cerebral blood flow (CBF) parameters. Specifically, arterial and venous oxygenation levels were determined with pulse oximetry and the novel T2 relaxation under spin tagging (TRUST) MRI, respectively. Global CBF was measured with phase contrast (PC) flow velocity MRI. The proposed method was implemented on a standard 3‐T MRI scanner without the need for any …
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P Liu, H Huang, N Rollins, LF Chalak, T Jeon… - NMR in biomedicine, 2014