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Assessment of brain hemodynamics without exogenous contrast agents is of increasing importance in clinical applications. This study aims to develop an MR perfusion technique that can provide noncontrast and multiparametric estimation of hemodynamic markers.

We devised an arterial spin labeling (ASL) method based on the principle of MR fingerprinting (MRF), referred to as MRF‐ASL. By taking advantage of the rich information contained in MRF sequence, up to seven hemodynamic parameters can be estimated concomitantly. Feasibility demonstration, flip angle optimization, comparison with Look‐Locker ASL, reproducibility test, sensitivity to hypercapnia challenge, and initial clinical application in an intracranial steno‐occlusive process, Moyamoya disease, were performed to evaluate this technique.

Magnetic resonance fingerprinting ASL provided estimation of up to seven …