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Cerretelli, Paolo, Mauro Marzorati, and Claudio Marconi. Muscle bioenergetics and metabolic control at altitude. High Alt. Med. Biol. 10: 165–174, 2009.—High altitude functional data, particularly those obtained on humans in the field by conventional techniques, appear to be often affected by a large variability that does not seem to be justified by the characteristics of the research protocols and by the adopted experimental procedures which, in most cases, are “state of the art”. This is also evident by the frequent occurrence of debates (e.g. “point – counterpoint” contributions by specialists in the Journal of Applied Physiology) on issues whose interpretation was taken for granted. The appearance of an exclusive new player, the multi-gene transcription protein Hypoxia Inducible Factor (HIF-1) recognized as the master regulator of cell hypoxic signaling, opens a new scenario. Indeed, among the genes regulated by …