作者
Jian Zheng, Joanne F Chou, Mithat Gönen, Neeta Vachharajani, William C Chapman, Maria B Majella Doyle, Simon Turcotte, Franck Vandenbroucke-Menu, Réal Lapointe, Stefan Buettner, Bas Groot Koerkamp, Jan NM Ijzermans, Chung Yip Chan, Brian KP Goh, Jin Yao Teo, Juinn Huar Kam, Prema R Jeyaraj, Peng Chung Cheow, Alexander YF Chung, Pierce KH Chow, London LPJ Ooi, Vinod P Balachandran, T Peter Kingham, Peter J Allen, Michael I D’Angelica, Ronald P DeMatteo, William R Jarnagin, Ser Yee Lee
发表日期
2017/10/1
期刊
Annals of surgery
卷号
266
期号
4
页码范围
693-701
出版商
LWW
简介
Objective:
This study aims to validate a previously reported recurrence clinical risk score (CRS).
Summary of Background Data:
Salvage transplantation after hepatocellular carcinoma (HCC) resection is limited to patients who recur within Milan criteria (MC). Predicting recurrence patterns may guide treatment recommendations.
Methods:
An international, multicenter cohort of R0 resected HCC patients were categorized by MC status at presentation. CRS was calculated by assigning 1 point each for initial disease beyond MC, multinodularity, and microvascular invasion. Recurrence incidences were estimated using competing risks methodology, and conditional recurrence probabilities were estimated using the Bayes theorem.
Results:
From 1992 to 2015, 1023 patients were identified, of whom 613 (60%) recurred at a median follow-up of 50 months. CRS was well validated in that all 3 factors remained independent …
学术搜索中的文章
J Zheng, JF Chou, M Gönen, N Vachharajani… - Annals of surgery, 2017