作者
Yuanhao Yang, Hannah Musco, Steve Simpson-Yap, Zhihong Zhu, Ying Wang, Xin Lin, Jiawei Zhang, Bruce Taylor, Jacob Gratten, Yuan Zhou
发表日期
2021/9/24
期刊
Nature communications
卷号
12
期号
1
页码范围
5641
出版商
Nature Publishing Group UK
简介
An epidemiological association between multiple sclerosis (MS) and inflammatory bowel disease (IBD) is well established, but whether this reflects a shared genetic aetiology, and whether consistent genetic relationships exist between MS and the two predominant IBD subtypes, ulcerative colitis (UC) and Crohn’s disease (CD), remains unclear. Here, we use large-scale genome-wide association study summary data to investigate the shared genetic architecture between MS and IBD overall and UC and CD independently. We find a significantly greater genetic correlation between MS and UC than between MS and CD, and identify three SNPs shared between MS and IBD (rs13428812), UC (rs116555563) and CD (rs13428812, rs9977672) in cross-trait meta-analyses. We find suggestive evidence for a causal effect of MS on UC and IBD using Mendelian randomization, but no or weak and inconsistent evidence for …
学术搜索中的文章
Y Yang, H Musco, S Simpson-Yap, Z Zhu, Y Wang… - Nature communications, 2021