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Synthesized titanium oxide nanoparticles (TiO₂-NPs) nanotubes were used for the disinfection of new emerging corona virus-19 (SARS-CoV-2) in this study. The newly synthesized TiO₂-NPs (nanotubes) were characterized by chemical spectroscopic analysis Fourier-transform infrared spectroscopy and ultraviolet FT-IR and UV. The chemical purity and Zeta potential distribution of the TiO₂-NPs (nanotubes) were evaluated to confirm their nano-range, and their surface morphology was determined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), high-resolution transmission electron microscopy (HR-TEM), and energy dispersive X-ray analysis (EDX). The antiviral activity of the TiO₂-NPs (nanotubes) against SARS-CoV-2 was evaluated using 10% (Dimethyl sulfoxide) DMSO and dist.H₂O using a cytotoxicity assay and inhibitory concentration assay (to determine the cytotoxic half concentration CC₅₀ and half maximal inhibitory concentration IC₅₀). The current results confirmed that TiO₂-NPs exhibit strong anti-SARS-CoV-2 activity at very low cytotoxic concentrations in vitro with a non-significant selectivity index (CC₅₀/IC₅₀ ≤ 1). The obtained results indicate that TiO₂-NPs and nanotubes have potent antiviral activity at a very low concentrations (IC₅₀ = 568.6 ng/mL), with a weak cytotoxic effect on the cellular host (CC₅₀ = 399.1 ng/mL). Thus, we highly recommend the use of TiO₂-NPs (nanotubes) in vitro and in wall coatings as a potent disinfectant to combat SARS-CoV-2 with little irritation of the cellular hosts. Furthermore, we also recommend more and excessive prospective studies on the complexation of …