作者
A Apostolidis, R Popat, Y Yiangou, D Cockayne, APDW Ford, JB Davis, P Dasgupta, CJ Fowler, P Anand
发表日期
2005/9
期刊
The Journal of urology
卷号
174
期号
3
页码范围
977-983
出版商
Wolters Kluwer
简介
Purpose
Botulinum neurotoxin type A (BoNT/A) is effective in the treatment of intractable detrusor overactivity (DO). In addition to its known inhibitory effect on presynaptic release of acetylcholine by motor terminals, there is increasing evidence that BoNT/A may affect sensory fibers. We investigated a possible effect of BoNT/A on human bladder afferent mechanisms by studying the sensory receptors P2X3 and TRPV1 in biopsies from patients with neurogenic or idiopathic DO.
Materials and Methods
A total of 38 patients (22 with neurogenic DO, 16 with idiopathic DO) with intractable DO were treated with intradetrusor BoNT/A, and bladder biopsies were taken at 4 and 16 weeks. Urodynamics and voiding diary were also recorded. Specimens were studied immunohistochemically for P2X3, TRPV1 and the pan-neuronal marker PGP9.5, in comparison with controls.
Results
P2X3-immunoreactive and TRPV1 …
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