作者
Irene Hervas Herrero, María Gil Juliá, Rocio Rivera-Egea, Javier Aquerreta Escribano, Amadeo Ten-Esteve, Leonor Cerdá Alberich, Saturnino Marco Luján, Luis Marti-Bonmati, Jose Remohi, Nicolas Garrido Puchalt
发表日期
2022/10/1
期刊
Fertility and Sterility
卷号
118
期号
4
页码范围
e290
出版商
Elsevier
简介
Objective
Currently, there are no available biomarkers that predict the presence of spermatogenic foci for guiding a testicular biopsy sampling, thus enhancing azoospermic patient’s likelihood of finding viable sperm. The aim is to determine new MR image biomarkers associated with the presence of spermatozoa to be used as a non-invasive tool for localizing active foci of spermatogenesis in non-obstructive azoospermia patients.
MATERIALS AND METHODS: This is the first phase of a prospective study, aiming establish normalcy image parameters. Seventeen volunteers within a sperm donation program underwent testicular area MR image from June 2021 to March 2022. Different image biomarkers representing tissue architecture were measured: magnetization transfer ratio (MTR), fat fraction (FF), apparent diffusion coefficient (ADC), diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction …
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IH Herrero, MG Juliá, R Rivera-Egea, JA Escribano… - Fertility and Sterility, 2022