作者
Irene Hervás, Alberto Pacheco, Rocío Rivera-Egea, Maria Gil Julia, Ana Navarro-Gomezlechon, Nicolás Garrido
发表日期
2022/6/1
期刊
Reproductive BioMedicine Online
卷号
44
期号
6
页码范围
1079-1089
出版商
Elsevier
简介
Research question
Does sperm DNA fragmentation (SDF) affect reproductive success of IVF and intracytoplasmic sperm injection (ICSI) cycles measured as cumulative live birth rates (CLBR) in unselected couples?
Design
Clinical data from 1339 couples undergoing 2759 IVF/ICSI cycles using autologous oocytes with a SDF test by TdT (terminal deoxynucleotidyl transferase)-mediated dUDP nick-end labelling (TUNEL) assay on their ejaculated spermatozoa were retrospectively evaluated. Main outcomes were calculated according to two different analyses: using 15% SDF as cut-off point (low ≤15% and high >15%); and categorizing participants based on four SDF ranges (<10%, 10– <20%, 20–30% and >30%). Live birth rate and CLBR per number of embryo transfers, per number of embryos replaced and consumed oocytes required to achieve the first live birth according to level of SDF were the main outcomes …
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I Hervás, A Pacheco, R Rivera-Egea, MG Julia… - Reproductive BioMedicine Online, 2022