作者
Dvir Aran, Marina Sirota, Atul J Butte
发表日期
2015/12/4
期刊
Nature communications
卷号
6
期号
1
页码范围
8971
出版商
Nature Publishing Group UK
简介
The tumour microenvironment is the non-cancerous cells present in and around a tumour, including mainly immune cells, but also fibroblasts and cells that comprise supporting blood vessels. These non-cancerous components of the tumour may play an important role in cancer biology. They also have a strong influence on the genomic analysis of tumour samples, and may alter the biological interpretation of results. Here we present a systematic analysis using different measurement modalities of tumour purity in >10,000 samples across 21 cancer types from the Cancer Genome Atlas. Patients are stratified according to clinical features in an attempt to detect clinical differences driven by purity levels. We demonstrate the confounding effect of tumour purity on correlating and clustering tumours with transcriptomics data. Finally, using a differential expression method that accounts for tumour purity, we find an …
学术搜索中的文章
D Aran, M Sirota, AJ Butte - Nature communications, 2015