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One alternative approach to diversify agricultural production is to integrate cropping with livestock production at the farm scale. Cropping, when possible, tends to become more important than animal production because, in general, it can feed more people per area unit in terms of calories and protein. In such systems, the role of wasteland grazing as a source of energy for agriculture through animals for traction and dung is often taken over by the use of resources from fossil reserves. This changing role of animals in the sustainability of agriculture is addressed in this paper to assess options and constraints for crop and animal production in crop-livestock farming system in Albanian part of Prespa Park (AL-Prespa). The paper summarizes the current state of mixed crop-livestock farming and assesses the factors affecting sustainability of crop-livestock farming, such as seasonal forage availability or suboptimal pasture utilization due to overgrazing, and emphasizes that Prespa area agriculture is essentially characterized by mixed farm operations in which crops and animals play an important part. This paper also assess future challenges, determine new opportunities, and present some remedies for sustainable intensification of crop-livestock systems, considers how the application of practices in sustainable crop-livestock farming may contribute to promoting sustainable land use and improving environment conservation, natural resource management, livelihoods of crop-livestock producers, and product quality. The taken results are encouraging.