作者
William D Leslie, Lisa M Lix, L Langsetmo, C Berger, David Goltzman, David A Hanley, JD Adachi, Helena Johansson, Anders Oden, Eugene McCloskey, John A Kanis
发表日期
2011/3
期刊
Osteoporosis international
卷号
22
页码范围
817-827
出版商
Springer-Verlag
简介
Summary
We describe the creation of a FRAX® model for the assessment of fracture probability in Canadian men and women, calibrated from national hip fracture and mortality data. This FRAX tool was used to examine possible thresholds for therapeutic intervention in Canada in two large complementary cohorts of women and men.
Objective
To evaluate a Canadian World Health Organization (WHO) fracture risk assessment (FRAX®) tool for computing 10-year probabilities of osteoporotic fracture.
Methods
Fracture probabilities were computed from national hip fracture data (2005) and death hazards (2004) for Canada. Probabilities took account of age, sex, clinical risk factors (CRFs), and femoral neck bone mineral density (BMD). Treatment implications were studied in two large cohorts of individuals age 50 years …
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WD Leslie, LM Lix, L Langsetmo, C Berger, D Goltzman… - Osteoporosis international, 2011