作者
Lora M Giangregorio, William D Leslie, Lisa M Lix, Helena Johansson, Anders Oden, Eugene McCloskey, John A Kanis
发表日期
2012/2/1
期刊
Journal of bone and mineral research
卷号
27
期号
2
页码范围
301-308
出版商
Wiley Subscription Services, Inc., A Wiley Company
简介
The study objective was to determine whether diabetes is a risk factor for incident hip or major osteoporotic fractures independent of the WHO fracture risk assessment tool (FRAX). Men and women with diabetes (n = 3518) and nondiabetics (n = 36,085) aged ≥50 years at the time of bone mineral density (BMD) testing (1990 to 2007) were identified in a large clinical database from Manitoba, Canada. FRAX probabilities were calculated, and fracture outcomes to 2008 were established via linkage with a populationbased data repository. Multivariable Cox proportional hazards models were used to determine if diabetes was associated with incident hip fractures or major osteoporotic fractures after controlling for FRAX risk factors. Mean 10year probabilities of fracture were similar between groups for major fractures (diabetic 11.1 ± 7.2 versus nondiabetic 10.9 ± 7.3, p = 0.116) and hip fractures …
引用总数
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学术搜索中的文章
LM Giangregorio, WD Leslie, LM Lix, H Johansson… - Journal of bone and mineral research, 2012