作者
Rocío G Urdinguio, Juan Ramon Tejedor, Manuel Fernández-Sanjurjo, Raúl F Pérez, Alfonso Peñarroya, Cecilia Ferrero, Helena Codina-Martínez, Carlos Díez-Planelles, Paola Pinto-Hernández, Juan Castilla-Silgado, Almudena Coto-Vilcapoma, Sergio Díez-Robles, Noelia Blanco-Agudín, Cristina Tomás-Zapico, Eduardo Iglesias-Gutiérrez, Benjamín Fernández-García, Agustin F Fernandez, Mario F Fraga
发表日期
2021/12/1
期刊
Molecular metabolism
卷号
54
页码范围
101398
出版商
Elsevier
简介
Objective
To analyze the genome-wide epigenomic and transcriptomic changes induced by long term resistance or endurance training in the hippocampus of wild-type mice.
Methods
We performed whole-genome bisulfite sequencing (WGBS) and RNA sequencing (RNA-seq) of mice hippocampus after 4 weeks of specific training. In addition, we used a novel object recognition test before and after the intervention to determine whether the exercise led to an improvement in cognitive function.
Results
Although the majority of DNA methylation changes identified in this study were training-model specific, most were associated with hypomethylation and were enriched in similar histone marks, chromatin states, and transcription factor biding sites. It is worth highlighting the significant association found between the loss of DNA methylation in Tet1 binding sites and gene expression changes, indicating the importance of …
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RG Urdinguio, JR Tejedor, M Fernández-Sanjurjo… - Molecular metabolism, 2021