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The way that we live influences our health, and during our lifespan we are exposed to a great diversity of compounds and stresses. There is growing evidence of epigenetic alterations that appear associated with external cues, however, the functional role that epigenetic mechanisms play in the response to environmental stimuli remains to be clarified. In this chapter, we will discuss how our lifestyle influences the epigenome, paying special attention to our diet, bad habits, and the stress that we are subject to on a daily basis. These epigenetic changes can affect the homeostasis of our cells and tissues, possibly playing a role in the development of disease.