作者
Joey W Trampush, Max Lam Zhan Yang, Jin Yu, Emma Knowles, Gail Davies, David C Liewald, John M Starr, Srdjan Djurovic, Ingrid Melle, K Sundet, Andrea Christoforou, Ivar Reinvang, Pamela DeRosse, AJ Lundervold, Vidar Martin Steen, Thomas Espeseth, Katri Räikkönen, Elisabeth Widén, Aarno Palotie, Johan Gunnar Eriksson, Ina Giegling, Bettina Konte, Panos Roussos, Stella Giakoumaki, Katherine E Burdick, Antony Payton, W Ollier, M Horan, Ornit Chiba-Falek, Deborah K Attix, Anna C Need, Elizabeth Trilby Cirulli, Aristotle N Voineskos, Nikos C Stefanis, D Avramopoulos, Alex Hatzimanolis, Dan E Arking, Nikolaos Smyrnis, Robert Martin Bilder, Nelson A Freimer, Tyrone D Cannon, Edyth London, Russell Alan Poldrack, Fred W Sabb, E Congdon, Emily Drabant Conley, Matthew A Scult, Dwight Dickinson, Richard E Straub, G Donohoe, D Morris, Aiden Corvin, Michael Gill, AR Hariri, Daniel R Weinberger, Neil Pendleton, Panos Bitsios, Dan Rujescu, Jari Lahti, Stephanie Le Hellard, Matthew C Keller, Ole Andreas Andreassen, Ian John Deary, David C Glahn, Anil K Malhotra, Todd Lencz
发表日期
2017/3
期刊
Molecular psychiatry
卷号
22
期号
3
页码范围
336-345
出版商
Nature Publishing Group
简介
The complex nature of human cognition has resulted in cognitive genomics lagging behind many other fields in terms of gene discovery using genome-wide association study (GWAS) methods. In an attempt to overcome these barriers, the current study utilized GWAS meta-analysis to examine the association of common genetic variation (~ 8M single-nucleotide polymorphisms (SNP) with minor allele frequency⩾ 1%) to general cognitive function in a sample of 35 298 healthy individuals of European ancestry across 24 cohorts in the Cognitive Genomics Consortium (COGENT). In addition, we utilized individual SNP lookups and polygenic score analyses to identify genetic overlap with other relevant neurobehavioral phenotypes. Our primary GWAS meta-analysis identified two novel SNP loci (top SNPs: rs76114856 in the CENPO gene on chromosome 2 and rs6669072 near LOC105378853 on chromosome 1 …
学术搜索中的文章
JW Trampush, MLZ Yang, J Yu, E Knowles, G Davies… - Molecular psychiatry, 2017