作者
Guadalupe Ayala, Lourdes Flores-Luna, Dulce Hernández-Amaro, Guillermo Mendoza-Hernández, Lilia Chihu-Amparán, Fernando Bernal-Sahagún, Margarita Camorlinga, Eduardo Lazcano-Ponce, Javier Torres
发表日期
2011/10
期刊
Cancer Causes & Control
卷号
22
页码范围
1425-1434
出版商
Springer Netherlands
简介
Objective
To study the association between anti-VacA antibodies and pre-neoplastic lesions (IM), gastric cancer (GC), and duodenal ulcer (DU).
Methods
A case–control study that included 347 patients, 90 with IM, 60 with GC, 52 with DU, and 145 with non-atrophic gastritis was conducted. For the analysis, a polytomous logistic regression models were used. Anti-VacA antibodies were identified in sera from these patients, either by Western blot assay (WB), using antigens produced by H. pylori s1m1 strain, or by neutralization assay challenging HeLa cells with H. pylori VacA s1m1 cytotoxin.
Results
Results of the WB assay showed no association between WB-anti-VacA antibodies and gastroduodenal diseases. In contrast, when antibodies that neutralize VacA cytotoxic activity were studied, a significant association was …
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